Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476304 | 1.00 | RAB9A (0.41) | RAB9AL3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL10897711 | 0.78 | KDM4E (0.43) | RAB9AL3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL11760944 | 0.78 | KDM4E (0.45) | RAB9AL3MBTL1TSHRKMT2ACYP1A2 | |
| SCHEMBL11760938 | 0.78 | KDM4E (0.45) | RAB9AL3MBTL1TSHRKMT2ACYP1A2 | |
| SCHEMBL5569624 | 0.75 | RAB9A (0.40) | RAB9AL3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL5569627 | 0.75 | RAB9A (0.40) | RAB9AL3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL9476996 | 0.74 | CYP1A2 (0.46) | L3MBTL1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9477003 | 0.74 | CYP1A2 (0.46) | L3MBTL1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1255150 | 0.73 | TRIM24 (0.52) | RAB9AL3MBTL1TSHRCASP3SENP8 | |
| SCHEMBL20954574 | 0.71 | KDM4E (0.36) | RAB9AKMT2ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |