SCHEMBL9476347

SCHEMBL9476347

CCOc1ccc(-c2ccc(CC=CF)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.48
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.41
NPC1 O15118 2/20 0.41
TP53 P04637 2/20 0.41
HSD17B10 Q99714 1/20 0.41
XDH P47989 1/20 0.41
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
RELA Q04206 1/20 0.40
PRSS1 P07477 1/20 0.40
PRSS2 P07478 1/20 0.40
PRSS3 P35030 1/20 0.40
LTA4H P09960 1/20 0.39
GRM2 Q14416 1/20 0.39
LMNA P02545 1/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9476334 1.00 NQO1 (0.48) NQO1TSHRTDP1RAB9ASMN1; SMN2
SCHEMBL9479520 0.87 CYP3A4 (0.44) RAB9ASMN1; SMN2KDM4ENPC1HSD17B10
SCHEMBL9476732 0.87 CYP2D6 (0.51) RAB9ASMN1; SMN2KDM4ENPC1HSD17B10
SCHEMBL9479529 0.87 CYP3A4 (0.44) RAB9ASMN1; SMN2KDM4ENPC1HSD17B10
SCHEMBL9476718 0.87 CYP2D6 (0.51) RAB9ASMN1; SMN2KDM4ENPC1HSD17B10
SCHEMBL9476615 0.84 RARB (0.49) RAB9ASMN1; SMN2NPC1LTA4HLMNA
SCHEMBL9476604 0.84 RARB (0.49) RAB9ASMN1; SMN2NPC1LTA4HLMNA
SCHEMBL9477453 0.83 NQO1 (0.45) NQO1TSHRTDP1RAB9ASMN1; SMN2
SCHEMBL9477467 0.83 NQO1 (0.45) NQO1TSHRTDP1RAB9ASMN1; SMN2
SCHEMBL9477491 0.83 RARB (0.51) TSHRRAB9ASMN1; SMN2NPC1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0377469-B1 A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-10-06 EP disclosed
US-5183587-A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-02-02 US disclosed
EP-0377469-A1 A liquid crystalline compound CHISSO CORPORATION (JP) 1990-07-11 EP disclosed