SCHEMBL9477453

SCHEMBL9477453

CCOc1ccc(-c2ccc(CC/C=C/F)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.45
RAB9A P51151 3/20 0.41
MAPT P10636 3/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
ACACB O00763 2/20 0.40
GPR84 Q9NQS5 1/20 0.40
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
NPC1 O15118 3/20 0.39
KDM4E B2RXH2 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 1/20 0.39
HSD17B10 Q99714 1/20 0.39
XDH P47989 1/20 0.39
FFAR1 O14842 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39
RELA Q04206 1/20 0.38
SLC5A1 P13866 1/20 0.38
SLC5A2 P31639 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9477467 1.00 NQO1 (0.45) NQO1RAB9AMAPTL3MBTL1ACACB
SCHEMBL9476765 0.88 CYP3A4 (0.49) SMN1; SMN2
SCHEMBL9475693 0.88 LMNA (0.48) RAB9AMAPTL3MBTL1ACACBNPC1
SCHEMBL9476777 0.88 CYP3A4 (0.49) SMN1; SMN2
SCHEMBL9475703 0.88 LMNA (0.48) RAB9AMAPTL3MBTL1ACACBNPC1
SCHEMBL9476546 0.85 CYP3A4 (0.48) RAB9ANPC1SMN1; SMN2
SCHEMBL9476540 0.85 CYP3A4 (0.48) RAB9ANPC1SMN1; SMN2
SCHEMBL9477104 0.84 CYP3A4 (0.50) RAB9ATSHRNPC1SMN1; SMN2TP53
SCHEMBL9477114 0.84 CYP3A4 (0.50) RAB9ATSHRNPC1SMN1; SMN2TP53
SCHEMBL9476334 0.83 NQO1 (0.48) NQO1RAB9AMAPTL3MBTL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0377469-B1 A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-10-06 EP disclosed
US-5183587-A LIQUID CRYSTALLINE COMPOUND CHISSO CORPORATION (JP) 1993-02-02 US disclosed
EP-0377469-A1 A liquid crystalline compound CHISSO CORPORATION (JP) 1990-07-11 EP disclosed