Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.49 |
| ▸ | RARB | P10826 | 4/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476480 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9477118 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9476687 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9475902 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9479205 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9479168 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9476333 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9652131 | 1.00 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9475424 | 0.98 | THRA (0.51) | THRATHRBPTPN11RARBRARA | |
| SCHEMBL9476493 | 0.91 | THRA (0.54) | THRATHRBPTPN11PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182047-A | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-26 | — | — | US | disclosed |
| EP-0368975-B1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1992-12-16 | — | — | EP | disclosed |