Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11023428 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL9476022 | 0.88 | ALDH1A1 (0.47) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL11022101 | 0.88 | KDM4E (0.50) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL10853277 | 0.86 | KDM4E (0.46) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL11017408 | 0.86 | KDM4E (0.46) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL9475251 | 0.85 | KDM4E (0.46) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL11024452 | 0.85 | KMT2A (0.48) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL11023628 | 0.85 | KDM4E (0.44) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL9476379 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL9477002 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212314-A | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5212315-A | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-18 | — | — | US | disclosed |
| EP-0140375-B1 | ALKOXYIMINO ETHER DERIVATIVES OF 5-ACYL-2(1H)-PYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-23 | — | — | EP | disclosed |
| US-5043449-A | Certain alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-27 | — | — | US | disclosed |
| US-4920229-A | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4849522-A | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS (US) | 1989-07-18 | — | — | US | disclosed |
| US-4732982-A | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-22 | — | — | US | disclosed |
| EP-0101952-B1 | 5-ALKYL-1,6-NAPHTHYRIDIN-2(1H)-ONES, INTERMEDIATES, THEIR PREPARATION AND THEIR CARDIOTONIC USE | STERLING DRUG INC. (US) | 1987-09-23 | — | — | EP | disclosed |
| EP-0204335-A2 | 2(1H)-Pyridin-ones useful as intermediates | STERLING DRUG INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| US-4595762-A | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles | STERLING DRUG INC. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4568751-A | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-04 | — | — | US | disclosed |
| US-4559347-A | 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic use and preparation thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4539327-A | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-09-03 | — | — | US | disclosed |
| US-4524149-A | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4517190-A | 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4469699-A | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0101952-A1 | 5-Alkyl-1,6-naphthyridin-2(1H)-ones, intermediates, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4415580-A | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same | STERLING DRUG INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4412077-A | Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone | STERLING DRUG INC. (US) | 1983-10-25 | — | — | US | disclosed |
| EP-0089022-A2 | Alkanoylpyridinones useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1983-09-21 | — | — | EP | disclosed |