Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9481047 | 0.82 | NPC1 (0.43) | HTTKCNJ1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL9479591 | 0.81 | EPHX2 (0.59) | HTR7SERPINE1PLGPLAUEPHX2 | |
| SCHEMBL8998162 | 0.80 | EPHX2 (0.52) | SERPINE1PLGPLAUEPHX2NR1H4 | |
| SCHEMBL9478930 | 0.77 | EPHX2 (0.51) | HTR7SERPINE1PLGPLAUEPHX2 | |
| SCHEMBL6086013 | 0.74 | SERPINE1 (0.54) | SERPINE1PLGPLAUHTTALDH1A1 | |
| SCHEMBL1666362 | 0.73 | HTT (0.44) | HTTKCNJ1MAPTTDP1CA12 | |
| SCHEMBL9479548 | 0.73 | EPHX2 (0.48) | SERPINE1EPHX2NR1H4HTTHPGD | |
| SCHEMBL9479006 | 0.73 | EPHX2 (0.44) | SERPINE1PLGPLAUEPHX2NR1H4 | |
| SCHEMBL9478402 | 0.73 | HDAC3 (0.52) | EPHX2NR1H4LMNA | |
| SCHEMBL15556148 | 0.72 | HTR7 (0.41) | HTR7ARHTTKCNJ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |