Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597486 | 0.85 | TSHR (0.44) | KDM4EGAAALDH1A1FUCA1CA12 | |
| SCHEMBL22084664 | 0.85 | KDM4E (0.37) | KDM4EGAAGLAALDH1A1FUCA1 | |
| SCHEMBL22032149 | 0.85 | KDM4E (0.37) | KDM4EGAAGLAALDH1A1FUCA1 | |
| SCHEMBL4989662 | 0.79 | SIRT6 (0.43) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL19211608 | 0.74 | SMN1; SMN2 (0.40) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL2886941 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL12126792 | 0.73 | TSHR (0.44) | KDM4EGAAALDH1A1CA12CA1 | |
| SCHEMBL23925965 | 0.73 | CA12 (0.42) | KDM4EGAAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL12126789 | 0.72 | MAPK1 (0.35) | KDM4EALDH1A1HPGDTDP1HSD17B10 | |
| SCHEMBL1339413 | 0.71 | CYP4F2 (0.44) | KDM4EGAAALDH1A1FUCA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |