Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099269 | 0.79 | MIF (0.43) | KMT2AMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9479915 | 0.75 | KMT2A (0.48) | KMT2AMAPTMEN1TDP1ALDH1A1 | |
| SCHEMBL9096667 | 0.71 | KMT2A (0.43) | KMT2AMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL9480093 | 0.71 | MAOB (0.55) | KMT2AMAPTSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL9099922 | 0.69 | KMT2A (0.43) | KMT2AMAPTSMN1; SMN2MEN1ALOX15 | |
| SCHEMBL1032753 | 0.69 | PARP10 (0.59) | KMT2AMAPTMEN1TDP1ALDH1A1 | |
| SCHEMBL28741088 | 0.69 | PRSS1 (0.65) | KMT2AMAPTMEN1TDP1ESR1 | |
| SCHEMBL29228749 | 0.69 | CYP11B1 (0.54) | KMT2AMAPTSMN1; SMN2MEN1ALOX15 | |
| SCHEMBL5652166 | 0.68 | GSK3B (0.54) | TDP1LMNAF2PRSS1ACR | |
| SCHEMBL31607774 | 0.68 | PTGDR2 (0.59) | KMT2AMAPTSMN1; SMN2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247381-B1 | 5-FLUROROURACIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5047521-A | Anticarcinogenic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0247381-A2 | 5-flurorouracil derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-12-02 | — | — | EP | disclosed |