Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | ACR | P10323 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652160 | 0.95 | GSK3B (0.59) | GSK3BTYMSVNN1PRSS1IRAK4 | |
| SCHEMBL7656344 | 0.90 | F2 (0.59) | GSK3BTYMSVNN1TDP1GPR139 | |
| SCHEMBL7650287 | 0.84 | GSK3B (0.59) | GSK3BTYMSVNN1F2LMNA | |
| SCHEMBL8394217 | 0.83 | PRSS1 (0.54) | GSK3BTYMSTDP1PRSS1ACR | |
| SCHEMBL19203281 | 0.82 | GSK3B (0.54) | GSK3BTYMSVNN1GPR139GRM5 | |
| SCHEMBL545343 | 0.81 | LMNA (0.58) | TDP1F2LMNATSHR | |
| SCHEMBL60040 | 0.81 | MRGPRX4 (0.56) | GSK3BGPR139GRM5TSHRPLAU | |
| SCHEMBL6972463 | 0.81 | GSK3B (0.56) | GSK3BTYMSVNN1PRSS1IRAK4 | |
| SCHEMBL17460156 | 0.81 | GSK3B (0.56) | GSK3BTYMSVNN1S1PR3PRSS1 | |
| SCHEMBL30444713 | 0.81 | MRGPRX4 (0.56) | GSK3BGPR139GRM5TSHRPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| US-4167407-A | 1-Thiadiazolyl-5-acylimidazolidinones | VELSICOL CHEMICAL CORPORATION (US) | 1979-09-11 | — | — | US | disclosed |
| US-4018787-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1977-04-19 | — | — | US | disclosed |