Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL800 | 0.85 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL775457 | 0.81 | ALDH1A1 (0.40) | ALDH1A1 | |
| Methylene Chloride SCHEMBL28135450 | 0.78 | HTT (0.31) | ALDH1A1 | |
| SCHEMBL801 | 0.76 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL27500855 | 0.76 | ALDH1A1 (0.65) | ALDH1A1 | |
| SCHEMBL25239528 | 0.73 | — | — | |
| SCHEMBL25238221 | 0.73 | ALDH1A1 (0.37) | ALDH1A1 | |
| SCHEMBL25286952 | 0.71 | HTT (0.30) | — | |
| SCHEMBL25285348 | 0.71 | HTT (0.31) | — | |
| SCHEMBL28841924 | 0.71 | HTT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5240915-A | Anthelmintics, parasiticides | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| US-4833168-A | ANTHELMINTICS | MERCK & CO., INC. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4806527-A | Avermectin derivatives | MERCK & CO., INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0284255-A1 | Avermectin derivatives | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0169038-B1 | C-8A-OXO-AVERMECTIN AND MILBEMYCIN DERIVATIVES | MERCK & CO. INC. (US) | 1988-07-20 | — | — | EP | disclosed |
| US-4622313-A | PARASITICIDES | MERCK & CO., INC. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0074758-B1 | 4A-SUBSTITUTED AVERMECTIN COMPOUNDS, THEIR PRODUCTION AND ANTIPARASITIC USE, AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1986-07-16 | — | — | EP | disclosed |
| EP-0169038-A2 | C-8a-oxo-avermectin and milbemycin derivatives | MERCK & CO. INC. (US) | 1986-01-22 | — | — | EP | disclosed |
| US-4547491-A | PARASITICIDES; ANTHELMINTICS; INSECTICIDES | MERCK & CO., INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4469682-A | PARASITICIDES | MERCK & CO., INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0115930-A1 | Avermectin and milbemycin phosphate esters | MERCK & CO. INC. (US) | 1984-08-15 | — | — | EP | disclosed |
| EP-0040913-B1 | 23-KETO DERIVATIVES OF C-076 COMPOUNDS, THEIR PREPARATION AND ANTI-PARASITIC USE | MERCK & CO. INC. (US) | 1984-07-25 | — | — | EP | disclosed |
| US-4457920-A | ANTIBIOTIC PARASITICIDES | MERCK & CO., INC. (US) | 1984-07-03 | — | — | US | disclosed |
| EP-0074758-A1 | 4a-Substituted avermectin compounds, their production and antiparasitic use, and compositions containing them | MERCK & CO. INC. (US) | 1983-03-23 | — | — | EP | disclosed |
| EP-0040913-A1 | 23-Keto derivatives of C-076 compounds, their preparation and anti-parasitic use | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | disclosed |