Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791057 | 1.00 | KDM4E (0.44) | KDM4EATMALDH1A1HTTLIPG | |
| SCHEMBL10482290 | 0.91 | KDM4E (0.41) | KDM4EATMALDH1A1HTTLIPG | |
| SCHEMBL9791240 | 0.88 | KDM4E (0.44) | KDM4EATMALDH1A1HTTLIPG | |
| SCHEMBL9484239 | 0.88 | KDM4E (0.43) | KDM4EATMALDH1A1HTTHRH3 | |
| SCHEMBL9791237 | 0.85 | KDM4E (0.42) | KDM4EATMALDH1A1HTTLIPG | |
| SCHEMBL9560318 | 0.84 | KDM4E (0.40) | KDM4EATMALDH1A1HTTKCNH2 | |
| SCHEMBL9791278 | 0.83 | KDM4E (0.44) | KDM4EATMALDH1A1HTTHRH3 | |
| Iodomethane SCHEMBL9791137 | 0.83 | KDM4E (0.40) | KDM4EATMALDH1A1HTTLIPG | |
| SCHEMBL9559970 | 0.82 | KDM4E (0.39) | KDM4EATMALDH1A1HTTHRH3 | |
| SCHEMBL16508608 | 0.82 | KDM4E (0.51) | KDM4EATMALDH1A1HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375348-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| EP-0358240-B1 | INTERMEDIATES FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0532674-A4 | LEUKOTRIENE ANTAGONISTS | — | 1993-04-07 | — | — | EP | disclosed |
| EP-0532674-A1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-5189226-A | Chemical intermediate for diacid | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5143931-A | 2-Phenyl-2((tetrazolyl or imidazolyl)thio)alkanoic acid derivatives; antiphylactic and bronchodilator agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0296731-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5135938-A | Bronchodilator | SMITHKLINE BEECHAM CORPORATION (US) | 1992-08-04 | — | — | US | disclosed |
| WO-1991018889-A1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |
| US-5034537-A | Alpha-methyl-4-halobenzenemethanamine salts of acids for cardiovascular disorders, respiratory system disorders and antiallergens | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0358240-A2 | Intermediates for the preparation of leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874792-A | RESPIRATORY SYSTEM DISORDERS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4871771-A | PHENYL SUBSTITUTED-DITHIA-ALKANEDIOIC ACIDS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0327306-A2 | Leukotriene B4 antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-08-09 | — | — | EP | disclosed |
| US-4820719-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIISCHEMIC AND HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0296731-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |
| US-4730005-A | DITHIA-ALKANEDIOIC ACIDS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0168902-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1987-09-30 | — | — | EP | disclosed |
| EP-0202759-A2 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1986-11-26 | — | — | EP | disclosed |
| EP-0168902-A1 | Leukotriene antagonists | SMITHKLINE BECKMAN CORPORATION (US) | 1986-01-22 | — | — | EP | disclosed |