Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593010 | 1.00 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL9486435 | 1.00 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL1042003 | 1.00 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL1900543 | 1.00 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL5933161 | 1.00 | — | — | |
| SCHEMBL5606540 | 1.00 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL5932738 | 0.97 | — | — | |
| SCHEMBL1042256 | 0.80 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL2698662 | 0.80 | TSHR (0.53) | TSHRTHRBALDH1A1DNM1LMNA | |
| SCHEMBL7694903 | 0.76 | TSHR (0.57) | TSHRTHRBALDH1A1DNM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322209-B1 | COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-02-10 | — | — | EP | claimed |
| US-4954339-A | ANTICHOLESTEROL AGENTS, SEQUESTERING | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-04 | — | — | US | claimed |
| WO-1989005828-A1 | COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-06-29 | — | — | WO | claimed |
| EP-0322209-A1 | Compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-06-28 | — | — | EP | claimed |
| EP-0322209-B1 | COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-02-10 | — | — | EP | disclosed |
| US-4954339-A | ANTICHOLESTEROL AGENTS, SEQUESTERING | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-04 | — | — | US | disclosed |
| WO-1989005828-A1 | COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322209-A1 | Compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |