Erythromycin

SCHEMBL9487690

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nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CYP3A4	P08684	8/20	0.94

▸	KCNH2	Q12809	5/20	0.94

▸	MLNR	O43193	3/20	0.94

▸	ABCB1	P08183	2/20	0.94

▸	TSHR	P16473	2/20	0.94

▸	LMNA	P02545	2/20	0.94

▸	TDP1	Q9NUW8	1/20	0.94

▸	ALB	P02768	1/20	0.94

▸	CNR1	P21554	1/20	0.94

▸	HTR2A	P28223	1/20	0.94

▸	AOX1	Q06278	1/20	0.94

▸	CYP1B1	Q16678	1/20	0.94

▸	SLCO1B3	Q9NPD5	2/20	0.87

▸	SLCO1B1	Q9Y6L6	2/20	0.87

▸	AR	P10275	1/20	0.87

▸	MAPK1	P28482	1/20	0.87

▸	PGR	P06401	1/20	0.83

▸	HTR1A	P08908	1/20	0.83

▸	DRD1	P21728	1/20	0.83

▸	SLC6A2	P23975	1/20	0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Erythromycin SCHEMBL153013	1.00	CYP3A4 (0.94)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL10620016	1.00	CYP3A4 (0.94)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL10620022	1.00	CYP3A4 (0.94)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL11201590	0.97	CYP3A4 (0.96)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL6395349	0.97	CYP3A4 (0.96)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL11503675	0.97	CYP3A4 (0.96)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL7056958	0.97	CYP3A4 (0.93)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL7056963	0.97	CYP3A4 (0.93)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL10900217	0.97	CYP3A4 (0.95)	CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL9054352	0.97	CYP3A4 (0.95)	CYP3A4KCNH2MLNRABCB1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0300888-B1	OPHTHALMIC COMPOSITION CONTAINING RHAMSAN GUM	LABORATOIRES MERCK, SHARP & DOHME-CHIBRET (FR)	1993-03-10	—	—	EP	disclosed
US-4996197-A	Pharmaceutical and/or cosmetic composition for local use containing Rhamsan gum	LABORATOIRES MERCK SHARP & DOHME-CHIBRET (FR)	1991-02-26	—	—	US	disclosed
EP-0300888-A1	Ophthalmic composition containing rhamsan gum	LABORATOIRES MERCK, SHARP & DOHME-CHIBRET (FR)	1989-01-25	—	—	EP	disclosed