Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11571218 | 0.98 | TP53 (0.44) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11571222 | 0.98 | TP53 (0.44) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| SCHEMBL6422615 | 0.98 | TP53 (0.48) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| SCHEMBL10835400 | 0.91 | TP53 (0.42) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| SCHEMBL30739512 | 0.89 | TP53 (0.41) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| SCHEMBL9745484 | 0.89 | TP53 (0.41) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| Sulfuric Acid SCHEMBL16824113 | 0.86 | TP53 (0.38) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| Sulfuric Acid SCHEMBL16824115 | 0.86 | TSHR (0.39) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| SCHEMBL19554399 | 0.86 | TSHR (0.65) | TP53TSHRCYP3A4TDP1ALDH1A1 | |
| Sulfuric Acid SCHEMBL16824117 | 0.82 | FLT1 (0.37) | TP53TSHRCYP3A4TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244686-B1 | PROCESS FOR THE MANUFACTURE OF AZO PIGMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-20 | — | — | EP | disclosed |
| EP-0290886-B1 | PROCESS FOR THE PREPARATION OF 2,5-DICHLOROPHENYLTHIOGLYCOLIC ACID | CASSELLA Aktiengesellschaft (DE) | 1992-01-08 | — | — | EP | disclosed |
| US-4920206-A | Process for making azo pigments | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-24 | — | — | US | disclosed |
| US-4918221-A | DIAZOTIZATION OF 2,5-DICHLOROANILINE, CATALYSIS, SALT FORMATION, HYDROLYSIS, AND CONDENSATION; AIR POLLUTION CONTROL; BY-PRODUCT INHIBITION | CASSELLA AG (DE) | 1990-04-17 | — | — | US | disclosed |
| EP-0290886-A1 | Process for the preparation of 2,5-dichlorophenylthioglycolic acid | CASSELLA Aktiengesellschaft (DE) | 1988-11-17 | — | — | EP | disclosed |
| EP-0067352-B2 | PROCESS FOR PREPARING S-ARYL-THIOGLYCOLIC ACIDS | BAYER AG (DE) | 1988-01-13 | — | — | EP | disclosed |
| EP-0067352-B1 | PROCESS FOR PREPARING S-ARYL-THIOGLYCOLIC ACIDS | BAYER AG (DE) | 1984-08-15 | — | — | EP | disclosed |
| US-4461911-A | FROM THIOGLYCOLIC ACID AND AN ARYLDIAZONIUM SALT, COPPER SALT, ACID MEDIUM | BAYER AKTIENGESELLSCHAFT (DE) | 1984-07-24 | — | — | US | disclosed |
| EP-0067352-A1 | Process for preparing S-aryl-thioglycolic acids | BAYER AG (DE) | 1982-12-22 | — | — | EP | disclosed |
| US-4046763-A | INTERMEDIATE FOR ULTRAVIOLET LIGHT ABSORBERS | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |