Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28671318 | 0.86 | CYP19A1 (0.43) | KAT2BCYP19A1MAPTAAK1CYP3A4 | |
| SCHEMBL278730 | 0.85 | ALDH1A1 (0.50) | KAT2BKMT2ALMNAMAPTHTT | |
| SCHEMBL3649190 | 0.83 | CYP19A1 (0.46) | CYP19A1MAPTAAK1CYP3A4TSHR | |
| SCHEMBL10959235 | 0.82 | TSHR (0.55) | KAT2BKMT2ALMNAMAPTHTT | |
| SCHEMBL27748882 | 0.81 | CYP19A1 (0.43) | KMT2ACYP19A1LMNAMAPTAAK1 | |
| SCHEMBL15248984 | 0.81 | ALDH1A1 (0.47) | CYP19A1MAPTAAK1CYP3A4TSHR | |
| SCHEMBL13344089 | 0.81 | KAT2B (0.48) | KAT2BKMT2ALMNAMAPTHTT | |
| SCHEMBL31449975 | 0.81 | CYP19A1 (0.40) | KMT2ACYP19A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28676747 | 0.80 | KCNH2 (0.48) | LMNACYP3A4ALDH1A1 | |
| SCHEMBL4313888 | 0.80 | CYP19A1 (0.42) | CYP19A1AAK1CYP3A4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011087738-A2 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |
| EP-0325892-B1 | PROCESS FOR THE PREPARATION OF HALOGENATED PRIMARY AMINES | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |
| EP-0473552-A1 | Process for the preparation of halogenated aromatic primary amines | CIBA-GEIGY AG (CH) | 1992-03-04 | — | — | EP | disclosed |
| US-4960936-A | Process for the preparation of halogenated aromatic primary amines | CIBA-GEIGY CORPORATION (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0325892-A2 | Process for the preparation of halogenated primary amines | CIBA-GEIGY AG (CH) | 1989-08-02 | — | — | EP | disclosed |