Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 3/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL310739 | 1.00 | — | — | |
| Bicarbonate SCHEMBL28880335 | 1.00 | TSHR (0.56) | TSHRCA1CA2CA9CAMK2A | |
| Bicarbonate SCHEMBL28828260 | 0.95 | — | — | |
| Bicarbonate SCHEMBL28043204 | 0.95 | — | — | |
| Bicarbonate SCHEMBL11775796 | 0.95 | TSHR (0.50) | TSHRCA1CA2CA9CAMK2A | |
| Bicarbonate SCHEMBL28468139 | 0.95 | — | — | |
| Bicarbonate SCHEMBL19410354 | 0.95 | TSHR (0.50) | TSHRCA1CA2CA9CAMK2A | |
| Bicarbonate SCHEMBL28227077 | 0.91 | TSHR (0.46) | TSHRCA1CA2CA9CAMK2A | |
| Cyclohexane SCHEMBL15408354 | 0.87 | TSHR (0.42) | TSHRCA1CA2CA9CAMK2A | |
| Oxalic Acid SCHEMBL468036 | 0.84 | TSHR (0.50) | TSHRCA1CA2CA9CAMK2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5191123-A | Catalytic decarboxylation with a metal oxide catalyst | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0478076-A2 | Processes for the preparation of hydroxyl-containing compounds | UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC. (US) | 1992-04-01 | — | — | EP | disclosed |