SCHEMBL9488367

SCHEMBL9488367

COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(CCNC(=O)N(C)C)cc12

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 2/20 0.62
CYSLTR1 Q9Y271 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9488822 0.92
SCHEMBL9490251 0.89 CYSLTR2 (0.49) CYSLTR2CYSLTR1
SCHEMBL9489366 0.87 CYSLTR2 (0.62) CYSLTR2CYSLTR1
SCHEMBL9489487 0.86 CYSLTR2 (0.60) CYSLTR2CYSLTR1
SCHEMBL9488345 0.85
SCHEMBL9488408 0.83 PLA2G4A (0.50)
SCHEMBL9490133 0.83 NQO2 (0.43)
SCHEMBL9488472 0.82
SCHEMBL10469115 0.82 CYSLTR2 (0.54) CYSLTR2CYSLTR1
SCHEMBL10470032 0.80 CYSLTR2 (0.53) CYSLTR2CYSLTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0337766-B1 HETERA-ALIPHATIC CARBOXAMIDES ICI AMERICAS INC. (US) 1993-03-10 EP claimed
EP-0337766-A1 Hetera-aliphatic carboxamides ICI AMERICAS INC. (US) 1989-10-18 EP claimed
EP-0337766-B1 HETERA-ALIPHATIC CARBOXAMIDES ICI AMERICAS INC. (US) 1993-03-10 EP disclosed
US-5041460-A Antiallergens, antiinflammatory agents and leukotriene antagonists ICI AMERICAS INC. (US) 1991-08-20 US disclosed
EP-0337766-A1 Hetera-aliphatic carboxamides ICI AMERICAS INC. (US) 1989-10-18 EP disclosed