Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.58 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489773 | 1.00 | AGTR1 (0.58) | AGTR1LTB4R2ABCB11GP6OPRM1 | |
| SCHEMBL682685 | 0.95 | AGTR1 (0.66) | AGTR1LTB4R2ABCB11GP6HDAC3 | |
| SCHEMBL9490562 | 0.95 | AGTR1 (0.66) | AGTR1LTB4R2ABCB11GP6HDAC3 | |
| SCHEMBL682686 | 0.90 | AGTR1 (0.63) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2820 | 0.90 | AGTR1 (0.74) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2178 | 0.90 | AGTR1 (0.74) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL683899 | 0.88 | AGTR1 (0.60) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL7271546 | 0.88 | AGTR1 (0.62) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL7271536 | 0.88 | AGTR1 (0.62) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2879 | 0.87 | AGTR1 (0.58) | AGTR1LTB4R2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260325-A | Hypotensive agents; treatment of congestive heart failure and angina | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-11-09 | — | — | US | disclosed |