Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948061 | 0.83 | HCAR2 (0.36) | ALDH1A1LMNATDP1CYP2C9CXCR1 | |
| SCHEMBL22290228 | 0.83 | NPSR1 (0.42) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL29262474 | 0.83 | KDM4C (0.38) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL16598697 | 0.81 | NPSR1 (0.37) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL7451996 | 0.79 | KDM4E (0.42) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL951010 | 0.78 | PDGFRB (0.41) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL950978 | 0.74 | NPSR1 (0.43) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL3141845 | 0.71 | CDK4 (0.40) | KDM4CKDM4ESTAT3HIF1ANPSR1 | |
| SCHEMBL22290167 | 0.71 | NPSR1 (0.44) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL69295 | 0.71 | NPSR1 (0.48) | KDM4CKDM4ESTAT3HIF1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451450-B1 | Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections | PASTEUR INSTITUT (FR) | 2014-07-02 | — | — | EP | disclosed |
| EP-2451450-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | Institut Pasteur (FR) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011004323-A1 | NEW INHIBITORS OF PROLINE RACEMASE ENZYMES | INSTITUT PASTEUR (FR) | 2011-01-13 | — | — | WO | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |