Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141854 | 0.92 | KDM4E (0.36) | CDK4CCND1GSK3BNPSR1MAPK1 | |
| SCHEMBL3136957 | 0.83 | HPGD (0.40) | NPSR1TP53MAPTALDH1A1GAA | |
| SCHEMBL4487940 | 0.82 | HPGD (0.41) | NPSR1TP53ALDH1A1 | |
| SCHEMBL13368926 | 0.79 | NPC1 (0.40) | NPSR1MAPK1TP53MAPTALDH1A1 | |
| SCHEMBL13755836 | 0.79 | NPSR1 (0.38) | NPSR1MAPK1MAPTGABRA2KDM4E | |
| SCHEMBL13523524 | 0.77 | NPSR1 (0.42) | NPSR1MAPK1TP53MAPTALDH1A1 | |
| SCHEMBL3392295 | 0.77 | ALDH1A1 (0.36) | ALDH1A1GABRG2GABRB3GABRA2 | |
| SCHEMBL13751486 | 0.77 | NPSR1 (0.42) | NPSR1MAPK1TP53MAPTALDH1A1 | |
| SCHEMBL13523542 | 0.76 | NPSR1 (0.35) | NPSR1MAPK1TP53MAPTKDM4E | |
| SCHEMBL13343759 | 0.76 | NPSR1 (0.35) | NPSR1MAPK1TP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE | 2010-05-06 | — | — | US | disclosed |
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE | 2010-05-06 | — | — | US | disclosed |
| WO-2010042758-A2 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-04-15 | — | — | WO | disclosed |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
| WO-2010011864-A2 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011864-A2 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | WO | disclosed |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-03 | — | — | US | disclosed |
| US-7579350-B2 | 5-Isobutyl-6-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridazin-3-yl]-piperidin-1-yl-methanone; mimetics of functionalized pyridazine derivatives having low molecular weight; alpha-helical binding ligands of natural receptors such as those of the peptide galanin or the protein Bcl | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579350-B2 | 5-Isobutyl-6-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridazin-3-yl]-piperidin-1-yl-methanone; mimetics of functionalized pyridazine derivatives having low molecular weight; alpha-helical binding ligands of natural receptors such as those of the peptide galanin or the protein Bcl | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-25 | — | — | US | disclosed |
| US-20090197895-A1 | OXAZOLE-PYRROLE-PIPERAZINE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-06 | — | — | US | disclosed |
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | HRH1, HEATR1, HSPH1 | CDK4 3784/4885CCND1 4620/4885GSK3B 2295/4885 |
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | OXA1L, H1-4, H1-5 | CDK4 408/4885CCND1 2450/4885GSK3B 2968/4885 |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | HRH1, HEATR1, PLEKHA1 | CDK4 3709/4885CCND1 4492/4885GSK3B 2875/4885 |
| US-20090197895-A1 | OXAZOLE-PYRROLE-PIPERAZINE ALPHA-HELIX MIMETIC | OXA1L, OCIAD1, OCIAD2 | CDK4 2085/4885CCND1 3820/4885GSK3B 2991/4885 |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | H1-4, H1-5, H1-3 | CDK4 587/4885CCND1 2287/4885GSK3B 3431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.