SCHEMBL9490225

SCHEMBL9490225

CCOC(=O)C(C)c1cc(O)ccc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 6/20 0.50
CA1 P00915 6/20 0.50
CA2 P00918 6/20 0.50
CA7 P43166 6/20 0.50
CA9 Q16790 6/20 0.50
CA14 Q9ULX7 6/20 0.50
ALDH1A1 P00352 3/20 0.43
TSHR P16473 1/20 0.43
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
ALOX5 P09917 1/20 0.40
PTGS2 P35354 1/20 0.40
HSP90AB1 P08238 1/20 0.39
MYC P01106 1/20 0.39
PTPN1 P18031 1/20 0.39
LMNA P02545 2/20 0.39
MEN1 O00255 1/20 0.39
TP53 P04637 1/20 0.39
KMT2A Q03164 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31502427 0.84 ALDH1A1 (0.42) ALDH1A1TSHRMYCLMNAMEN1
SCHEMBL490900 0.83 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL1744701 0.81 CA12 (0.47) CA12CA1CA2CA7CA9
SCHEMBL9489701 0.80 KDM4E (0.52) ALDH1A1TSHRLMNAMEN1KMT2A
SCHEMBL490708 0.80 CA12 (0.54) CA12CA1CA2CA7CA9
SCHEMBL19695886 0.79 SMN1; SMN2 (0.49) ALDH1A1LMNATP53KMT2AMAPT
SCHEMBL39297 0.78 CA12 (0.48) CA12CA1CA2CA7CA9
SCHEMBL38825 0.77 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL27949294 0.77 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL10580575 0.76 CA12 (0.43) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0362714-B1 LIQUID-CRYSTALLINE COMPOUNDS AND LIQUID-CRYSTALLINE POLYMERS IDEMITSU KOSAN COMPANY LIMITED (JP) 1993-03-24 EP disclosed