Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL14353233 | 1.00 | FFAR3 (0.41) | FFAR3TSHRTP53MAPTHDAC1 | |
| Bicarbonate SCHEMBL13372634 | 1.00 | FFAR3 (0.41) | FFAR3TSHRTP53MAPTHDAC1 | |
| Bicarbonate SCHEMBL14244821 | 1.00 | FFAR3 (0.41) | FFAR3TSHRTP53MAPTHDAC1 | |
| Succinic Acid SCHEMBL28576541 | 0.84 | LMNA (0.53) | FFAR3TSHRHDAC1HDAC2TDP1 | |
| SCHEMBL10888733 | 0.82 | FFAR3 (0.40) | FFAR3TSHRTP53MAPTTDP1 | |
| Bicarbonate SCHEMBL47991 | 0.81 | FFAR3 (0.44) | FFAR3TSHRTP53HDAC1HDAC2 | |
| Bicarbonate SCHEMBL3793442 | 0.81 | FFAR3 (0.44) | FFAR3TSHRTP53HDAC1HDAC2 | |
| Bicarbonate SCHEMBL13372557 | 0.81 | FFAR3 (0.44) | FFAR3TSHRTP53HDAC1HDAC2 | |
| Methyl Alcohol SCHEMBL11524367 | 0.81 | — | — | |
| SCHEMBL7654 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276465-B1 | PROCESS FOR PRODUCING LIGHT FLAT ARTICLES USING AQUEOUS DISPERSIONS OR EMULSIONS OF ORGANIC COMPOUNDS CONTAINING NCO GROUPS, AND THE ARTICLES THUS PREPARED | BASF Aktiengesellschaft (DE) | 1993-02-17 | — | — | EP | disclosed |