Triflumuron

Triflumuron

SCHEMBL9490691

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(OC(F)(F)F)cc1.O=C(NC(=O)c1ccccc1Cl)Nc1ccc(OC(F)(F)F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 1.00
EPHX2 P34913 3/20 0.60
GCGR P47871 1/20 0.58
MAPT P10636 2/20 0.56
RAB9A P51151 4/20 0.55
NPC1 O15118 3/20 0.55
POLB P06746 1/20 0.55
PKM P14618 1/20 0.55
RORC P51449 1/20 0.54
ALDH1A1 P00352 2/20 0.54
PLCG2 P16885 1/20 0.52
KDM4E B2RXH2 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.50
GAA P10253 2/20 0.50
HTT P42858 1/20 0.50
IGF1R P08069 1/20 0.50
MEN1 O00255 1/20 0.49
XBP1 P17861 1/20 0.49
KMT2A Q03164 1/20 0.49
FAAH O00519 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triflumuron SCHEMBL29832813 1.00 TDP1 (1.00) TDP1EPHX2GCGRMAPTRAB9A
Triflumuron SCHEMBL23700 1.00 TDP1 (1.00) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL9327703 0.97 TDP1 (0.95) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL11241126 0.90 TDP1 (0.81) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL10800847 0.90 TDP1 (0.82) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL515847 0.89 TDP1 (0.80) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL10780203 0.88 TDP1 (0.79) TDP1GCGRMAPTRAB9ANPC1
SCHEMBL27847099 0.88 TDP1 (0.78) TDP1EPHX2GCGRMAPTRAB9A
SCHEMBL11316756 0.88 TDP1 (0.78) TDP1MAPTRAB9ANPC1POLB
SCHEMBL10710076 0.87 TDP1 (0.77) TDP1EPHX2GCGRMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5266324-A Processes and agents for combating fleas BAYER AKTIENGESELLSCHAFT (DE) 1993-11-30 US disclosed
EP-0515893-A1 Substituted 4-heteroarylpyrazolines BAYER AG (DE) 1992-12-02 EP disclosed