Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.41 |
| ▸ | HTR1D known ✓ | P28221 | 2/20 | 0.41 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | HTR2C | P28335 | 7/20 | 0.53 |
| ▸ | HTR2B | P41595 | 6/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154428 | 0.98 | DRD4 (0.64) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL1091532 | 0.86 | MAPT (0.54) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL10122766 | 0.84 | KDM4E (0.49) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL30839280 | 0.84 | KDM4E (0.49) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL549646 | 0.81 | F7 (0.56) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL29924038 | 0.81 | F7 (0.56) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL29175983 | 0.80 | AHR (0.54) | DRD4DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL17461314 | 0.80 | AHR (0.54) | DRD4DRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8645796 | 0.79 | F7 (0.55) | DRD4DRD2HTR2AHTR2CHTR2B | |
| Ammonia Solution, Strong SCHEMBL7043924 | 0.79 | F7 (0.55) | DRD4DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009389-A1 | IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20070004736-A1 | Imidazole derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-04 | — | — | US | disclosed |
| EP-1564213-A1 | IMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004736-A1 | Imidazole derivative, process for producing the same, and use | HRH4, F2, HRH2 | ADRA2A 964/4885ADRA2B 906/4885ADRA2C 862/4885 |
| US-20110009389-A1 | IMIDAZOLE DERIVATIVE, THEIR PRODUCTION AND USE | F2, H1-3, CYC1 | ADRA2A 1464/4885ADRA2B 1352/4885ADRA2C 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.