Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491876 | 0.86 | LMNA (0.41) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9491872 | 0.86 | LMNA (0.41) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9493193 | 0.82 | — | — | |
| SCHEMBL9491952 | 0.73 | LMNA (0.44) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9491949 | 0.73 | LMNA (0.44) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9494278 | 0.70 | LMNA (0.52) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9494274 | 0.70 | LMNA (0.52) | ALDH1A1LMNARECQLMAPTMAPK1 | |
| SCHEMBL9493184 | 0.67 | GAA (0.30) | TSHR | |
| SCHEMBL9493188 | 0.67 | GAA (0.30) | TSHR | |
| SCHEMBL9492241 | 0.66 | LMNA (0.39) | ALDH1A1LMNARECQLMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494047-A1 | Use of carbazones for the treatment of rheumatoid diseases | CIBA-GEIGY AG (CH) | 1992-07-08 | — | — | EP | claimed |
| US-5177091-A | Rheumatic disorders | CIBA-GEIGY CORPORATION (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0494047-A1 | Use of carbazones for the treatment of rheumatoid diseases | CIBA-GEIGY AG (CH) | 1992-07-08 | — | — | EP | disclosed |