Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490857 | 0.80 | HTR2A (0.49) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL28838297 | 0.78 | HTR2A (0.53) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL18421289 | 0.78 | HTR2A (0.53) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL18416426 | 0.78 | HTR2A (0.53) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL10695561 | 0.78 | ADRA2B (0.62) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL11102215 | 0.74 | ADRA2B (0.57) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| Benzphetamine SCHEMBL49120 | 0.73 | ADRA2B (1.00) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| Benzphetamine SCHEMBL19285634 | 0.73 | ADRA2B (1.00) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| Benzphetamine SCHEMBL678807 | 0.73 | ADRA2B (1.00) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL15003030 | 0.73 | ADRA2B (0.71) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362001-B1 | N-CYCLOALKYL BENZYLAMINES ALPHA,ALPHA DISUBSTITUTED, THE PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND THEIR SYNTHESIS INTERMEDIATES | JOUVEINAL S.A. (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0361990-B1 | DISUBSTITUTED BENZYLAMINES, THE PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND THEIR SYNTHESES INTERMEDIATES | JOUVEINAL S.A. (FR) | 1993-02-24 | — | — | EP | disclosed |
| US-5089639-A | N-CYCLOALKYLALKYLAMINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT AND THEIR SYNTHESIS INTERMEDIATES | JOUVEINAL S.A. (FR) | 1992-02-18 | — | — | US | disclosed |
| US-5034419-A | Psychological disorders or gastrointestinal disorders | L'OREAL (FR) | 1991-07-23 | — | — | US | disclosed |
| US-5017723-A | Psychotropic Agents | JOUVEINAL S.A. (FR) | 1991-05-21 | — | — | US | disclosed |
| EP-0362001-A1 | N-cycloalkyl benzylamines alpha,alpha disubstituted, the process for their preparation, their use as drugs and their synthesis intermediates | JOUVEINAL S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |
| EP-0361990-A1 | Disubstituted benzylamines, the process for their preparation, their use as drugs and their syntheses intermediates | JOUVEINAL S.A. (FR) | 1990-04-04 | — | — | EP | disclosed |