SCHEMBL9492602

SCHEMBL9492602

Cc1ccc2nc(C(Cl)(Cl)Cl)cc(Cl)c2c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.64
NT5E P21589 2/20 0.49
ELANE P08246 2/20 0.45
MAPT P10636 2/20 0.44
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
ADRB2 P07550 3/20 0.43
ADRA2A P08913 1/20 0.42
HTR2C P28335 1/20 0.42
AXL P30530 1/20 0.42
HRH1 P35367 1/20 0.42
HTR2B P41595 1/20 0.42
HTR6 P50406 1/20 0.42
MKNK1 Q9BUB5 1/20 0.42
MKNK2 Q9HBH9 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
PKM P14618 1/20 0.40
DHODH Q02127 1/20 0.40
ACHE P22303 2/20 0.39
BCHE P06276 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10507034 0.88 LMNA (0.62) LMNANT5EELANEMAPTKDM4E
SCHEMBL10505012 0.88 LMNA (0.62) LMNANT5EELANEMAPTKDM4E
SCHEMBL1536650 0.86 NT5E (0.66) LMNANT5EELANEMAPTKDM4E
SCHEMBL9492838 0.86 LMNA (0.46) LMNANT5EMAPTKDM4EALDH1A1
SCHEMBL30492152 0.86 NT5E (0.66) LMNANT5EELANEMAPTKDM4E
SCHEMBL9493144 0.82 NT5E (0.51) LMNANT5EMAPTKDM4EALDH1A1
SCHEMBL10824071 0.82 NT5E (0.59) LMNANT5EMAPTALDH1A1DHODH
SCHEMBL9492496 0.81 NT5E (0.50) LMNANT5EMAPTDHODH
SCHEMBL9494556 0.79 SMN1; SMN2 (0.47) LMNANT5EMAPTKDM4EALDH1A1
SCHEMBL4768081 0.78 LMNA (1.00) LMNAELANEMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0113432-B1 CHLOROMETHYL QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE ALKALOIDA VEGYéSZETI GYáR (HU) 1993-03-17 EP claimed
US-4599345-A BACTERICIDES, FUNGICIDES ANTIINFLAMMATORY ALKALOIDE VEGYESZETI GYAR (HU) 1986-07-08 US claimed
EP-0113432-A1 Chloromethyl quinoline derivatives, process for their preparation and their use ALKALOIDA VEGYéSZETI GYáR (HU) 1984-07-18 EP claimed
EP-0113432-B1 CHLOROMETHYL QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE ALKALOIDA VEGYéSZETI GYáR (HU) 1993-03-17 EP disclosed
EP-0111329-B1 FLUOROMETHYL QUINOLINE DERIVATIVES AND THEIR PREPARATION ALKALOIDA VEGYESZETI GYAR (HU) 1989-03-15 EP disclosed
US-4599345-A BACTERICIDES, FUNGICIDES ANTIINFLAMMATORY ALKALOIDE VEGYESZETI GYAR (HU) 1986-07-08 US disclosed
EP-0113432-A1 Chloromethyl quinoline derivatives, process for their preparation and their use ALKALOIDA VEGYéSZETI GYáR (HU) 1984-07-18 EP disclosed
EP-0111329-A1 Fluoromethyl quinoline derivatives and their preparation ALKALOIDA VEGYESZETI GYAR (HU) 1984-06-20 EP disclosed