Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628160 | 0.83 | CNR1 (0.34) | MPO | |
| SCHEMBL4796197 | 0.77 | CNR1 (0.42) | — | |
| SCHEMBL27821973 | 0.75 | NOS2 (0.43) | MPO | |
| SCHEMBL6128069 | 0.75 | POLB (0.47) | TLR8 | |
| SCHEMBL11688903 | 0.73 | POLB (0.46) | TLR8KDR | |
| SCHEMBL23709236 | 0.72 | KDR (0.38) | TLR8KDRMPO | |
| SCHEMBL284028 | 0.71 | CNR1 (0.55) | TLR8 | |
| SCHEMBL10625859 | 0.70 | CNR1 (0.41) | TLR8 | |
| SCHEMBL10707345 | 0.70 | NPC1 (0.38) | TLR8KDRMPO | |
| SCHEMBL2791515 | 0.70 | KDM4E (0.36) | TLR8KDRMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320750-B1 | PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED-3-METHYL-1-ARYL-5-AMINO-PYRAZOLES | BAYER AG (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-4895957-A | Process for the preparation of 4-substituted 3-methyl-1-aryl-5-amino-pyrazoles | BAYER AKTIENGESELLSCHAFT (DE) | 1990-01-23 | — | — | US | disclosed |
| EP-0320750-A2 | Process for the preparation of 4-substituted-3-methyl-1-aryl-5-amino-pyrazoles | BAYER AG (DE) | 1989-06-21 | — | — | EP | disclosed |