Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24117805 | 0.78 | PTGDR2 (0.53) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL28285317 | 0.77 | MEN1 (0.82) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL15856598 | 0.76 | OGFRL1 (0.53) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL15856601 | 0.76 | OGFRL1 (0.50) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL17222490 | 0.76 | OGFRL1 (0.53) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL17222491 | 0.76 | OGFRL1 (0.53) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL7753647 | 0.75 | OPRM1 (0.62) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL17232245 | 0.75 | KDM4E (0.46) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL17232256 | 0.75 | KDM4E (0.46) | MEN1KMT2AKDM4EOPRM1OPRL1 | |
| SCHEMBL24117804 | 0.74 | OPRL1 (0.49) | KDM4EOPRM1OPRL1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321516-B1 | 3-INDOLEPYRUVIC ACID DERIVATIVES AND PHARMACEUTICAL USE THEREOF | POLIFARMA S.p.A. (IT) | 1993-03-03 | — | — | EP | disclosed |
| US-5002963-A | Central Nervous System Disorders | POLIFARMA S.P.A. (IT) | 1991-03-26 | — | — | US | disclosed |