Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9546910 | 0.97 | SNCA (0.55) | CA1CA2TSHRSNCARAB9A | |
| Hydrochloric Acid SCHEMBL1509558 | 0.95 | SNCA (0.58) | CA1CA2TSHRSNCARAB9A | |
| Bromide SCHEMBL197541 | 0.92 | SNCA (0.61) | CA1CA2TSHRSNCARAB9A | |
| Bromide SCHEMBL10773250 | 0.88 | SNCA (0.56) | CA1CA2TSHRSNCARAB9A | |
| Hydrochloric Acid SCHEMBL8123098 | 0.85 | SLC7A5 (0.60) | TSHRSNCARAB9AMAPTLOXL2 | |
| Bromide SCHEMBL5228525 | 0.84 | SLC7A5 (0.56) | CA1CA2TSHRSNCARAB9A | |
| Bromide SCHEMBL31614317 | 0.82 | SLC7A5 (0.60) | TSHRSNCARAB9AMAPTLOXL2 | |
| Bromide SCHEMBL1532873 | 0.82 | SLC7A5 (0.60) | TSHRSNCARAB9AMAPTLOXL2 | |
| Hydrochloric Acid SCHEMBL9519563 | 0.80 | TSHR (0.64) | CA1CA2TSHRRAB9ANPC1 | |
| Bromide SCHEMBL11685473 | 0.80 | KDM4E (0.46) | CA1CA2SNCARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212269-A | Main chain chromophoric polymers with second order nonlinear optical properties | UNITED STATES OF AMERICA, THE, AS REPRESENTED BY THE SECRETARY OF THE NAVY | 1993-05-18 | — | — | US | disclosed |