Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191583 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL13363312 | 0.83 | POLB (0.53) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL11081950 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL31369008 | 0.80 | KMT2A (0.50) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL30843858 | 0.80 | CYP3A4 (0.53) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL9430268 | 0.80 | KDM4E (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL9430272 | 0.80 | CYP3A4 (0.53) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL11786411 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EALDH1A1KMT2AHSD17B10 | |
| SCHEMBL13531559 | 0.79 | HSD17B10 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7277168 | 0.78 | KDM4E (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |