Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 4/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22615060 | 0.82 | KDM4E (0.54) | RAB9ANPC1KDM4EMAPTNR1I3 | |
| SCHEMBL9498700 | 0.82 | NPC1 (0.58) | RAB9ANPC1KDM4EMAPTPOLB | |
| SCHEMBL25789153 | 0.72 | NPC1 (0.44) | RAB9ANPC1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL24463224 | 0.71 | KDM4E (0.47) | RAB9ANPC1KDM4EMAPTPOLB | |
| SCHEMBL22614948 | 0.71 | KDM4E (0.45) | RAB9ANPC1KDM4EMAPTNR1I3 | |
| SCHEMBL22615012 | 0.71 | PLAU (0.49) | RAB9ANPC1KDM4EMAPTNR1I3 | |
| SCHEMBL18203556 | 0.70 | RAB9A (0.51) | RAB9ANPC1KDM4EMAPTNR1I3 | |
| SCHEMBL9042063 | 0.70 | PDE9A (0.32) | KDM4EMAPTHTTALDH1A1GLA | |
| SCHEMBL24517108 | 0.70 | KDM4E (0.44) | RAB9ANPC1KDM4EMAPTNR1I3 | |
| SCHEMBL24517330 | 0.70 | PLAU (0.46) | RAB9ANPC1KDM4EMAPTNR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5225414-A | SUBSTITUTED AZOLES, A PROCESS FOR THEIR PREPARATION, AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | disclosed |
| EP-0468372-A2 | Substituted azoles, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-29 | — | — | EP | disclosed |