Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | PTAFR | P25105 | 1/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | PRKCG | P05129 | 2/20 | 0.57 |
| ▸ | PRKCB | P05771 | 2/20 | 0.57 |
| ▸ | PRKCA | P17252 | 2/20 | 0.57 |
| ▸ | PRKCH | P24723 | 2/20 | 0.57 |
| ▸ | PRKCI | P41743 | 2/20 | 0.57 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.57 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.57 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806652 | 0.87 | ADRA1D (0.57) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10807926 | 0.86 | ADRA1D (0.69) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10814907 | 0.86 | ADRA1D (0.69) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL4007176 | 0.86 | ADRA1D (0.69) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10808632 | 0.86 | ADRA1D (0.69) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL2290669 | 0.86 | ADRA1D (0.69) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10816393 | 0.85 | ADRA1D (0.70) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10816865 | 0.85 | ADRA1D (0.70) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Bromide SCHEMBL9863596 | 0.84 | ADRA1D (0.56) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL10812395 | 0.83 | ADRA1D (0.61) | ADRA1DPTAFRHTR1DHTR2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208223-A | Enzyme inhibitors | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5144045-A | Treatment of inflammatory related disorders | AMERICAN CYANAMID COMPANY (US) | 1992-09-01 | — | — | US | disclosed |