⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569044 | 0.82 | TSHR (0.72) | — | |
| Guvacine SCHEMBL336053 | 0.80 | — | — | |
| SCHEMBL18808188 | 0.78 | — | — | |
| Guvacine SCHEMBL1057880 | 0.78 | BLM (1.00) | — | |
| Guvacine SCHEMBL9569008 | 0.78 | TSHR (0.96) | — | |
| SCHEMBL6215781 | 0.78 | — | — | |
| SCHEMBL20314870 | 0.78 | TSHR (0.60) | — | |
| SCHEMBL9497394 | 0.78 | TSHR (0.60) | — | |
| Norarecoline SCHEMBL3019132 | 0.78 | CHRM3 (1.00) | — | |
| Hydrochloric Acid SCHEMBL5245635 | 0.77 | BLM (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271798-B1 | O-SUBSTITUTED TETRAHYDROPYRIDINE OXIME CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-04-07 | — | — | EP | claimed |
| US-4786648-A | ANALGESIC | WARNER-LAMBERT COMPANY (US) | 1988-11-22 | — | — | US | claimed |
| EP-0271798-A2 | O-Substituted tetrahydropyridine oxime cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-06-22 | — | — | EP | claimed |
| US-20230148653-A1 | ARECOLINE SALT AND PREPARATION METHOD AND PRODUCT THEREOF | SHENZHEN HERUI BIOTECHNOLOGY CO., LTD. (CN) | 2023-05-18 | — | — | US | disclosed |
| US-20210292330-A1 | PYRROLIDINE-FUSED HETEROCYCLES | ERASCA, INC. | 2021-09-23 | — | — | US | disclosed |
| US-4786648-A | ANALGESIC | WARNER-LAMBERT COMPANY (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0271798-A2 | O-Substituted tetrahydropyridine oxime cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-06-22 | — | — | EP | disclosed |