Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Guvacine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.58 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.96 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guvacine SCHEMBL336053 | 0.98 | — | — | |
| Guvacine SCHEMBL1057880 | 0.96 | BLM (1.00) | TSHRSLC6A1SLC6A13BLMCHRM3 | |
| SCHEMBL9569044 | 0.82 | TSHR (0.72) | TSHRSLC6A1SLC6A13BLMCHRM3 | |
| SCHEMBL9499237 | 0.78 | — | — | |
| SCHEMBL18808188 | 0.78 | — | — | |
| SCHEMBL29439268 | 0.78 | TSHR (0.67) | TSHRSLC6A1SLC6A13BLMCHRM3 | |
| SCHEMBL6215781 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL5245635 | 0.77 | BLM (0.68) | TSHRSLC6A1SLC6A13BLMCHRM3 | |
| Norarecoline SCHEMBL8872254 | 0.76 | CHRM3 (0.96) | TSHRSLC6A1SLC6A13BLMCHRM3 | |
| SCHEMBL17897341 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537993-A1 | Nicotinic activity of a series of arecolones and isoarecolones | ELI LILLY AND COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |