Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 6/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658682 | 1.00 | ACE (0.49) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL27204055 | 0.85 | CTSS (0.47) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL27203759 | 0.85 | CTSS (0.47) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL19329718 | 0.84 | CTSS (0.54) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL19329712 | 0.84 | CTSS (0.54) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL7859251 | 0.82 | ACE (0.52) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL7859254 | 0.82 | ACE (0.52) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL1748990 | 0.81 | ACE (0.53) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL1748989 | 0.81 | ACE (0.53) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL269930 | 0.81 | ACE (0.58) | ACEITGB3ITGA2BPTPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216124-A | Analgesics | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5169833-A | Analgesics | G. D. SEARLE & CO. (US) | 1992-12-08 | — | — | US | disclosed |
| US-4722922-A | RENIN INHIBITION | G. D. SEARLE & CO. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4603121-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1986-07-29 | — | — | US | disclosed |
| EP-0136720-A2 | Enkephalin analogs | G.D. Searle & Co. (US) | 1985-04-10 | — | — | EP | disclosed |
| US-4495178-A | Enkephalin analogs | G. D. SEARLE & CO. (US) | 1985-01-22 | — | — | US | disclosed |