Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | APEX1 | P27695 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.59 |
| ▸ | PGR | P06401 | 3/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177096 | 0.94 | TDP1 (0.69) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL9488708 | 0.91 | TDP1 (0.59) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL10695981 | 0.91 | NR1I2 (0.61) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL9487671 | 0.91 | TDP1 (0.59) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL10694770 | 0.90 | TDP1 (0.58) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL10690357 | 0.90 | NR1I2 (0.60) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL9845771 | 0.89 | TDP1 (0.69) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL10696758 | 0.88 | NR1I2 (0.57) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL8988425 | 0.88 | TDP1 (0.67) | TDP1MAPTHSD17B10APEX1ALDH1A1 | |
| SCHEMBL9489625 | 0.88 | TDP1 (0.67) | TDP1MAPTHSD17B10APEX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416814-A2 | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates | BEECHAM GROUP PLC (GB) | 1991-03-13 | — | — | EP | claimed |
| EP-0521887-A1 | CEPHALOSPORINS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014692-A1 | CEPHALOSPORINS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1991-10-03 | — | — | WO | disclosed |
| EP-0416814-A2 | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates | BEECHAM GROUP PLC (GB) | 1991-03-13 | — | — | EP | disclosed |