Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 4/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499433 | 0.88 | SLC6A4 (0.71) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL27327439 | 0.87 | SLC6A4 (0.69) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| Sulfuric Acid SCHEMBL9500009 | 0.84 | SLC6A4 (0.64) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL16992804 | 0.84 | SLC6A4 (0.67) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL5011928 | 0.83 | SLC6A4 (1.00) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL8197696 | 0.83 | SLC6A4 (1.00) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL4941345 | 0.81 | SLC6A4 (0.97) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL13107035 | 0.80 | SLC6A4 (0.82) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL5015289 | 0.80 | SLC6A4 (0.82) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 | |
| SCHEMBL5268848 | 0.80 | SLC6A4 (0.82) | SLC6A4KMT2ACYP2D6CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |