SCHEMBL5015289

SCHEMBL5015289

CNCCC(Oc1ccc(C)cc1)c1ccccc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 14/20 0.82
KMT2A Q03164 5/20 0.70
LMNA P02545 5/20 0.70
CYP2D6 P10635 5/20 0.70
CYP3A4 P08684 5/20 0.70
SLC6A2 P23975 5/20 0.70
MEN1 O00255 4/20 0.70
HTR2C P28335 4/20 0.70
SLC6A3 Q01959 4/20 0.70
CYP1A2 P05177 4/20 0.70
TSHR P16473 3/20 0.70
CHRM1 P11229 3/20 0.70
ADRA2B P18089 3/20 0.70
HTR2A P28223 3/20 0.70
HRH1 P35367 3/20 0.70
OPRM1 P35372 3/20 0.70
OPRK1 P41145 3/20 0.70
HTR2B P41595 3/20 0.70
KCNH2 Q12809 3/20 0.70
HRH3 Q9Y5N1 3/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13107035 1.00 SLC6A4 (0.82) SLC6A4KMT2ALMNACYP2D6CYP3A4
Hydrochloric Acid SCHEMBL17685574 0.98 SLC6A4 (0.79) SLC6A4KMT2ALMNACYP2D6CYP3A4
Hydrochloric Acid SCHEMBL4942454 0.98 SLC6A4 (0.79) SLC6A4KMT2ALMNACYP2D6CYP3A4
Oxalic Acid SCHEMBL16347641 0.93 SLC6A4 (0.71) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL15257454 0.91 SLC6A4 (0.68) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL5011928 0.90 SLC6A4 (1.00) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL8197696 0.90 SLC6A4 (1.00) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL12546452 0.90 SLC6A4 (0.67) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL17280835 0.90 SLC6A4 (0.66) SLC6A4KMT2ALMNACYP2D6CYP3A4
SCHEMBL12546610 0.90 SLC6A4 (0.66) SLC6A4KMT2ALMNACYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761478-B1 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS TEVA PHARM FINE CHEMICALS SRL (IT) 2008-09-03 EP claimed
EP-0831799-B1 COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS NPS PHARMA INC (US) 2003-05-02 EP claimed
US-12491157-B1 Atomoxetine hydrochloride oral suspension and use thereof OWP Pharmaceuticals, Inc. 2025-12-09 US disclosed
US-12478584-B1 Atomoxetine hydrochloride oral suspension and use thereof OWP PHARMACEUTICALS INC (US) 2025-11-25 US disclosed
US-11779859-B2 Continuous production of active pharmaceutical ingredients NEW JERSEY INSTITUTE OF TECHNOLOGY (US) 2023-10-10 US disclosed
WO-2021202906-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED, INC. (DELAWARE) (US) 2021-10-07 WO disclosed
US-20180099060-A1 ORGANIC COMPOUNDS INTRA-CELLULAR THERAPIES, INC. 2018-04-12 US disclosed
US-9604906-B2 Process for the preparation of 3-aryloxy-3-phenylpropylamine and salt thereof ZCL CHEMICALS LIMITED (IN) 2017-03-28 US disclosed
US-20160107983-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE AND SALT THEREOF COHANCE LIFESCIENCES LIMITED (IN) 2016-04-21 US disclosed
US-8772330-B2 Inhibitor(s) of transporters or uptake of monoaminergic neurotransmitters STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) 2014-07-08 US disclosed
US-20120190725-A1 INHIBITOR(S) OF TRANSPORTERS OR UPTAKE OF MONOAMINERGIC NEUROTRANSMITTERS STATE UNIVERSITY 2012-07-26 US disclosed
EP-1761478-A2 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS Teva Pharmaceutical Fine Chemicals S.R.L. (IT) 2007-03-14 EP disclosed
EP-1761478-A2 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS Teva Pharmaceutical Fine Chemicals S.R.L. (IT) 2007-03-14 EP disclosed
EP-1715856-A1 ATOMOXETINE FORMULATIONS Actavis Group HF (IS) 2006-11-02 EP disclosed
WO-2006004979-A3 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS TEVA PHARM FINE CHEMICALS SRL (IT) 2006-04-13 WO disclosed
WO-2006037055-A1 SYNTHESIS OF ATOMOXETINE HYDROCHLORIDE DR. REDDY'S LABORATORIES LTD. (IN) 2006-04-06 WO disclosed
WO-2006004979-A2 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L. (IT) 2006-01-12 WO disclosed
WO-2006004979-A2 AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L. (IT) 2006-01-12 WO disclosed
US-20060009532-A1 Isolated atomoxetine impurity, processes for the preparation of atomoxetine impurities and their use as reference standards TEVA PHARMCEUTICALS USA, INC. 2006-01-12 US disclosed
WO-2005065673-A1 ATOMOXETINE FORMULATIONS ACTAVIS GROUP HF (IS) 2005-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12491157-B1 Atomoxetine hydrochloride oral suspension and use thereof SLC6A4, SLC6A3, MBOAT4 SLC6A4 1/4885KMT2A 74/4885LMNA 3814/4885
US-20120190725-A1 INHIBITOR(S) OF TRANSPORTERS OR UPTAKE OF MONOAMINERGIC NEUROTRANSMITTERS SLC6A2, SLC18A2, SLC6A3 SLC6A4 4/4885KMT2A 1304/4885LMNA 3799/4885
US-20060009532-A1 Isolated atomoxetine impurity, processes for the preparation of atomoxetine impurities and their use as reference standards PNMT, HTR3C, TH SLC6A4 34/4885KMT2A 112/4885LMNA 1367/4885
US-20160107983-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE AND SALT THEREOF PAH, TYR, NAT1 SLC6A4 162/4885KMT2A 1003/4885LMNA 1704/4885
US-12478584-B1 Atomoxetine hydrochloride oral suspension and use thereof SLC6A4, SLC6A3, MBOAT4 SLC6A4 1/4885KMT2A 74/4885LMNA 3814/4885
US-20180099060-A1 ORGANIC COMPOUNDS SLC6A2, PNMT, SLC6A4 SLC6A4 3/4885KMT2A 2761/4885LMNA 2306/4885
US-11779859-B2 Continuous production of active pharmaceutical ingredients SAMM50, VMA21, CYP3A4 SLC6A4 3223/4885KMT2A 4626/4885LMNA 3823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.