Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ASPH | Q12797 | 2/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28228895 | 0.84 | CA2 (0.56) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL21371036 | 0.81 | CA2 (0.58) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL9502803 | 0.80 | HIF1A (0.39) | KDM4EKMT2AMEN1MAPTPTGER2 | |
| SCHEMBL31703859 | 0.75 | KMT2A (0.50) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL4405351 | 0.74 | CYP2C9 (0.49) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL15470920 | 0.72 | CA2 (0.55) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL12427631 | 0.72 | PLK1 (0.67) | TSHRHDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL29950022 | 0.70 | CA2 (0.66) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL4404451 | 0.70 | TSHR (0.56) | TSHRCA2CA13CA12CA1 | |
| SCHEMBL19478209 | 0.70 | CA2 (0.47) | TSHRCA2CA13CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1021967-C | Process for preparing quinoline derivatives | DAINIPPON PHARMACEUTICAL CO (JP) | 1993-09-01 | — | — | CN | disclosed |
| EP-0312085-B1 | NOVEL QUINOLINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND ANTIBACTERIAL AGENT CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-5164392-A | Active against streptococci and staphylococci | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| US-5013841-A | Oxo quinoline derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-07 | — | — | US | disclosed |
| CN-1033996-A | New quinoline and their preparation method | DAINIPPON PHARMACEUTICAL CO (JP) | 1989-07-19 | — | — | CN | disclosed |
| EP-0312085-A2 | Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-04-19 | — | — | EP | disclosed |