Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.68 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CASP1 | P29466 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9499696 | 0.98 | NOTUM (0.66) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL1749207 | 0.87 | NOTUM (0.81) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL2766365 | 0.86 | NOTUM (0.64) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL18395507 | 0.86 | NOTUM (0.64) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL16595544 | 0.84 | NOTUM (0.67) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL20494916 | 0.82 | NOTUM (0.59) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL13896503 | 0.82 | MAPT (0.66) | NOTUMDEGS1ALDH1A1MAPTMAPK1 | |
| SCHEMBL28292789 | 0.81 | AKR1C3 (0.50) | NOTUMALDH1A1MAPTKMT2AAKR1C3 | |
| SCHEMBL9500414 | 0.81 | NOTUM (0.68) | NOTUMALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL16695357 | 0.81 | NOTUM (1.00) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101018769-A | Dimeric piperidine derivates | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | CN | disclosed |
| EP-0325268-B1 | 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5162342-A | USE OF 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS FOR ANALGESIA AND MUSCLE RELAXATION | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5064838-A | 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS AS PAIN RELIEVERS | MERRELL DOW PHARMACEUTICALS (US) | 1991-11-12 | — | — | US | disclosed |
| CN-1041363-A | PROCESS FOR PREPARING IMIDAZOLE ANTIARRHYTHMICS | MERRELL DOW PHARMA (US) | 1990-04-18 | — | — | CN | disclosed |
| CN-1035823-A | 1, the 4-Disubstituted-piperidnyl compounds | MERRELL DOW PHARMA (US) | 1989-09-27 | — | — | CN | disclosed |
| EP-0325268-A1 | 1,4-Disubstituted-piperidinyl compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-07-26 | — | — | EP | disclosed |