Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503714 | 0.86 | KCNH2 (0.51) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| SCHEMBL9501145 | 0.85 | KCNH2 (0.87) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL34157 | 0.82 | KCNH2 (1.00) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| SCHEMBL10774220 | 0.82 | KCNH2 (0.83) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL29695614 | 0.82 | KCNH2 (1.00) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL34156 | 0.82 | KCNH2 (1.00) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL34155 | 0.82 | KCNH2 (1.00) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL1230941 | 0.82 | KCNH2 (0.98) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| Grepafloxacin SCHEMBL29419670 | 0.82 | KCNH2 (0.98) | KCNH2HRH3GSK3BKDM4EALDH1A1 | |
| SCHEMBL9500988 | 0.82 | KCNH2 (0.81) | KCNH2HRH3GSK3BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312085-B1 | NOVEL QUINOLINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND ANTIBACTERIAL AGENT CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-5164392-A | Active against streptococci and staphylococci | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| US-5013841-A | Oxo quinoline derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-07 | — | — | US | disclosed |
| EP-0312085-A2 | Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-04-19 | — | — | EP | disclosed |