Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502093 | 0.86 | KCNH2 (0.70) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9504545 | 0.84 | KCNH2 (0.63) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9501954 | 0.82 | KCNH2 (0.58) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9501093 | 0.80 | GSK3B (0.54) | KCNH2HRH3KDM4EGSK3B | |
| SCHEMBL10813681 | 0.76 | KDM4E (0.74) | KDM4EALDH1A1LMNAHPGDMAPT | |
| SCHEMBL10546585 | 0.73 | GSK3B (0.55) | KCNH2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL10550876 | 0.73 | GSK3B (0.63) | GSK3B | |
| SCHEMBL10769737 | 0.73 | KCNH2 (0.45) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8199125 | 0.73 | KCNH2 (0.74) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9502058 | 0.72 | ADRB2 (0.48) | KDM4EALDH1A1LMNANPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0312085-B1 | NOVEL QUINOLINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND ANTIBACTERIAL AGENT CONTAINING THEM | Dainippon Pharmaceutical Co., Ltd. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-5164392-A | Active against streptococci and staphylococci | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-17 | — | — | US | disclosed |
| US-5013841-A | Oxo quinoline derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-07 | — | — | US | disclosed |
| EP-0312085-A2 | Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-04-19 | — | — | EP | disclosed |