Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 2/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9298864 | 0.90 | TNF (0.53) | ALDH1A1CYP1A2CYP2C19CYP2C9TNF | |
| SCHEMBL8560863 | 0.87 | GALR3 (0.50) | ALDH1A1TNFGALR3NR2F2RAB9A | |
| SCHEMBL8567343 | 0.85 | GALR3 (0.48) | ALDH1A1TNFGALR3NR2F2RAB9A | |
| SCHEMBL9298869 | 0.84 | TNF (0.61) | ALDH1A1CYP1A2CYP2C19CYP2C9TNF | |
| SCHEMBL8130341 | 0.83 | HDAC1 (0.56) | ALDH1A1TNFGALR3NR2F2RAB9A | |
| SCHEMBL9299653 | 0.83 | TNF (0.59) | ALDH1A1CYP1A2CYP2C19CYP2C9TNF | |
| SCHEMBL8139358 | 0.82 | HDAC1 (0.54) | ALDH1A1TNFGALR3NR2F2RAB9A | |
| SCHEMBL9300153 | 0.82 | TNF (0.57) | ALDH1A1CYP1A2CYP2C19TNFGALR3 | |
| SCHEMBL8129724 | 0.81 | MMP2 (0.57) | ALDH1A1TNFPOLBGALR3NR2F2 | |
| SCHEMBL8124045 | 0.80 | HDAC1 (0.53) | ALDH1A1CYP2C9TNFGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543861-A1 | IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003422-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | claimed |
| EP-0543861-A1 | IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5180723-A | Hypertensives, bronchodilators, antiedemic agents | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-01-19 | — | — | US | disclosed |
| WO-1992003422-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |