Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 16/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.52 |
| ▸ | FABP3 | P05413 | 1/20 | 0.52 |
| ▸ | SELPLG | Q14242 | 1/20 | 0.50 |
| ▸ | PTGFR | P43088 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10581093 | 0.93 | DHODH (0.67) | DHODHCYP2C9CYP3A4CYP2C8PDE10A | |
| SCHEMBL10583621 | 0.90 | DHODH (0.57) | DHODHCYP2C9CYP3A4CYP2C8PDE10A | |
| SCHEMBL9503665 | 0.88 | DHODH (0.55) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL8792771 | 0.87 | DHODH (0.56) | DHODHCYP2C9CYP3A4CYP2C8FABP4 | |
| SCHEMBL18075849 | 0.84 | DHODH (0.70) | DHODHCYP2C9PDE10AFABP4FABP5 | |
| SCHEMBL8793696 | 0.80 | DHODH (0.51) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL9501979 | 0.76 | DHODH (1.00) | DHODHCYP2C9CYP3A4CYP2C8PDE10A | |
| SCHEMBL1292111 | 0.75 | DHODH (0.72) | DHODHCYP2C9CYP3A4CYP2C8PDE10A | |
| SCHEMBL9501955 | 0.75 | DHODH (0.81) | DHODHCYP2C9CYP3A4CYP2C8PDE10A | |
| SCHEMBL9502241 | 0.75 | DHODH (0.82) | DHODHCYP2C9CYP3A4CYP2C8PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | claimed |
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |