Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | SELPLG | Q14242 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10581093 | 0.90 | DHODH (0.67) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL9502225 | 0.88 | DHODH (0.62) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL10583621 | 0.86 | DHODH (0.57) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL9505300 | 0.81 | KMO (0.41) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL8793696 | 0.76 | DHODH (0.51) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL9505334 | 0.76 | DHODH (0.77) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL8792771 | 0.75 | DHODH (0.56) | DHODHCYP2C9CYP3A4CYP2C8FABP4 | |
| SCHEMBL18075849 | 0.73 | DHODH (0.70) | DHODHCYP2C9FABP4FABP5FABP3 | |
| SCHEMBL9502241 | 0.71 | DHODH (0.82) | DHODHCYP2C9CYP3A4CYP2C8CYP1A2 | |
| SCHEMBL2373074 | 0.68 | DHODH (0.57) | DHODHCYP2C9CYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | claimed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | claimed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | claimed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |