Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2962759 | 0.83 | PIM1 (0.35) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2971821 | 0.80 | PIM1 (0.33) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2969087 | 0.79 | PTPN1 (0.38) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2962733 | 0.79 | PIM1 (0.37) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2967448 | 0.78 | PTPN1 (0.40) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2974062 | 0.78 | PTPN1 (0.40) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2972158 | 0.78 | PTPN1 (0.40) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2969701 | 0.78 | PTPN1 (0.40) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL2959826 | 0.78 | PTPN1 (0.40) | PIM1CSNK1A1CDK5ROCK1DYRK1A | |
| SCHEMBL15544896 | 0.75 | SIGMAR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008166-A1 | BENZO-ISOQUINOLINE DERIVATIVES AND ANALOGS AND THEIR USE IN THERAPEUTICS | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |
| EP-0539209-A1 | Benzo-isoquinoline derivatives and analogs and their use in therapeutics | THE UPJOHN COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |