Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502900 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA4NPC1ALDH1A1RAB9A | |
| SCHEMBL8215476 | 0.85 | KMT2A (0.39) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL466882 | 0.84 | KMT2A (0.40) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9502363 | 0.81 | CHRNB2 (0.59) | CHRNB2CHRNA4NPC1ALDH1A1RAB9A | |
| SCHEMBL9504116 | 0.77 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRM1LMNACHRM2 | |
| SCHEMBL9504121 | 0.77 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRM1LMNACHRM2 | |
| SCHEMBL10564080 | 0.76 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRM1LMNACHRM2 | |
| SCHEMBL10564077 | 0.76 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRM1LMNACHRM2 | |
| SCHEMBL9506150 | 0.75 | CHRM2 (0.50) | CHRNB2CHRNA4CHRM1LMNACHRM2 | |
| SCHEMBL10566192 | 0.75 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRM1LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291673-B1 | TETRAHYDROPYRIDINE OXIMES, A PROCESS FOR THEIR PREPARATION AND USE THEREOF AS CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-06-02 | — | — | EP | claimed |
| US-4929734-A | ANTIINFLAMMATORY AGENTS, ANTIDEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1990-05-29 | — | — | US | claimed |
| US-4798841-A | COGNITION ACTIVATORS, ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1989-01-17 | — | — | US | claimed |
| EP-0291673-A1 | Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-11-23 | — | — | EP | claimed |
| EP-0291673-B1 | TETRAHYDROPYRIDINE OXIMES, A PROCESS FOR THEIR PREPARATION AND USE THEREOF AS CHOLINERGIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5073561-A | N-substituted-pyridinyl oximes | WARNER-LAMBERT COMPANY (US) | 1991-12-17 | — | — | US | disclosed |
| US-4929734-A | ANTIINFLAMMATORY AGENTS, ANTIDEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4798841-A | COGNITION ACTIVATORS, ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1989-01-17 | — | — | US | disclosed |
| EP-0291673-A1 | Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4710508-A | ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1987-12-01 | — | — | US | disclosed |