Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 18/20 | 0.85 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9505839 | 0.93 | DHODH (0.79) | DHODHPDE10A | |
| SCHEMBL10582434 | 0.92 | DHODH (1.00) | DHODHPDE10A | |
| SCHEMBL10582007 | 0.87 | DHODH (0.77) | DHODHPDE10A | |
| SCHEMBL9505334 | 0.87 | DHODH (0.77) | DHODHPDE10A | |
| SCHEMBL7686140 | 0.83 | DHODH (0.79) | DHODHPDE10AKDM4EALDH1A1 | |
| SCHEMBL11238594 | 0.81 | DHODH (0.62) | DHODHPDE10AKDM4EALDH1A1 | |
| SCHEMBL9501990 | 0.81 | DHODH (0.84) | DHODHPDE10AAURKAKDRAURKB | |
| SCHEMBL17594005 | 0.79 | DHODH (0.94) | DHODHPDE10A | |
| SCHEMBL9505820 | 0.79 | DHODH (0.63) | DHODHPDE10A | |
| SCHEMBL10580105 | 0.79 | DHODH (0.89) | DHODHPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |