Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.65 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RARB | P10826 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502439 | 0.92 | MAPT (0.62) | PLK1PLA2G4BTSHRMAPTMAPK1 | |
| SCHEMBL9505675 | 0.91 | MAPT (0.61) | PLK1PLA2G4BTSHRMAPTMAPK1 | |
| SCHEMBL9362298 | 0.89 | ACAT1 (0.73) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9361404 | 0.89 | ACAT1 (0.70) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9361276 | 0.89 | ACAT1 (0.67) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9365181 | 0.89 | ACAT1 (0.73) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9362439 | 0.89 | ACAT1 (0.73) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9365091 | 0.89 | ACAT1 (0.70) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9365138 | 0.88 | ACAT1 (0.66) | PLK1TSHRMAPTMAPK1HDAC1 | |
| SCHEMBL9361811 | 0.88 | ACAT1 (0.66) | PLK1TSHRMAPTMAPK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543884-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ATHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003408-A1 | BENZANILIDE DERIVATIVES AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS | RHONE-POULENC RORER LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |